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Povišena je koncentracija diazepama u plazmi usled inhibicije CYP3A4 metaboličkog puta. U studiji kod zdravih dobrovoljaca primena 200 mg itrakonazola dnevno tokom 4 dana povećala je PIK pojedinačne oralne doze od 5 mg diazepama za oko fifteen%, ali ova interakcija nije bila od kliničkog značaja, što je potvrđeno psihomotornim testovima. Mo

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The concomitant use of tramadol hydrochloride tablets and CYP3A4 inhibitors can improve the plasma concentration of tramadol and may lead to a increased degree of metabolism by using CYP2D6 and bigger levels of M1. Observe patients closely for improved risk of great adverse events which include seizures and serotonin syndrome, and adverse reactions

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